arXiv q-bio.NC· Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Karin Oshima, Yohei Ishishita, Kenji Ibayashi, Yoshiyuki Onuki, Naoto Kunii, Kensuke Kawai, Hirokazu Takahashi·· 6 小时前AI 评分20
迷走神经刺激增强大鼠皮层 beta 与 gamma 速率听觉稳态响应
Vagus nerve stimulation strengthens beta- and gamma-rate auditory steady-state responses in rat cortex
AI 导读
在 7 只异氟烷麻醉大鼠中，30 Hz 颈部迷走神经刺激（VNS）增强了 click 诱发的 P1-N1 振幅。40 Hz 串刺激下，40 Hz 的 ITPC 与 ERSP 仅在听觉核心区升高；20 Hz 串刺激下，20 Hz ITPC 在核心区、带区和 IAF 升高，ERSP 与 40 Hz 谐波响应仅在核心区升高，AIC 无变化。
正文 · 原文
Abstract:Background: Gamma entrainment using sensory stimulation (GENUS) is under study as a treatment for neurological disease, but cortical engagement is variable. Vagus nerve stimulation (VNS) modulates cortical state and sound-evoked beta-gamma activity, suggesting that it may strengthen responses to rhythmic sensory input. Objective: To determine whether VNS strengthens auditory steady-state responses across beta and gamma rates and whether the effect depends on cortical region and sensory drive. Methods: Electrocorticography (ECoG) was recorded from core and belt auditory cortex, insular auditory field (IAF), and anterior insular cortex (AIC) in seven isoflurane-anesthetized rats before and 90 min after initiation of 30-Hz cervical VNS. Responses to 500-ms click trains at 20 and 40 Hz were quantified using inter-trial phase clustering (ITPC), event-related spectral perturbation (ERSP), and debiased weighted phase-lag index (WPLI). Results: VNS increased click-evoked P1-N1 amplitude. During 40-Hz trains, 40-Hz ITPC and ERSP increased only in auditory core. During 20-Hz trains, 20-Hz ITPC increased in core, belt, and IAF, whereas ERSP increased only in core; 40-Hz harmonic responses increased only in core. AIC showed no change. Within auditory cortex, WPLI increased selectively at frequencies present in each click train and not in the alpha band. Conclusions: VNS strengthened beta- and gamma-rate stimulus-locked responses in auditory-driven cortex without globally increasing synchrony. VNS may therefore enhance auditory cortical target engagement during GENUS, although effects on disease pathology or clinical outcomes remain untested.
| Subjects: | Neurons and Cognition (q-bio.NC) |
| Cite as: | arXiv:2610.29042 [q-bio.NC] |
| (or arXiv:2610.29042v1 [q-bio.NC] for this version) | |
| https://doi.org/10.48550/arXiv.2610.29042 arXiv-issued DOI via DataCite (pending registration) |
Submission history
From: Hirokazu Takahashi [view email]
[v1]
Wed, 21 Oct 2026 01:16:58 UTC (2,785 KB)
来源：arXiv q-bio.NC · arxiv.org