大规模神经科学时代的整合神经控制论建模
Integrative neurocybernetic modeling in the era of large-scale neuroscience
Il Memming Park 等人在 arXiv 发表 Perspective，提出整合神经控制论模型，将大脑视为追求潜在目标的控制器，刻画脑、身体与环境的闭环耦合。作者主张用非线性状态空间模型结合元动力学扩展、可扩展推断与知识蒸馏，并混合开环与闭环训练，把目标从孤立预测神经记录转向推断支配神经与行为动力学的组织原则。
Authors:Il Memming Park, Gonzalo G. de Polavieja, Ayesha Vermani, Juan Álvaro Gallego, Kathleen Esfahany, Shreya Saxena, Guillaume Hennequin, Michael Orger, Auke Ijspeert, Matthew Dowling, Daniel McNamee, Srinivas C. Turaga, Zachary Mainen, Alfonso Renart, Joseph J. Paton
Abstract:Large-scale neuroscience is generating rich datasets across animals, brain areas, and behavioral contexts, yet our modeling efforts remain fragmented across isolated experiments. We argue that understanding behavior requires integrative neurocybernetic models: understandable dynamical models that capture the closed-loop coupling of brain, body, and environment, treat the brain as a controller pursuing latent objectives, represent structured variation across scales, and scale to heterogeneous datasets. Such models shift the goal from predicting neural recordings in isolation to inferring the organizing principles that govern neural and behavioral dynamics. We outline a practical route toward this goal by combining nonlinear state-space models and meta-dynamical extensions with scalable inference, knowledge distillation, and mixed open- and closed-loop training. By pooling complementary constraints from recordings, behavior, perturbations, and anatomy, integrative neurocybernetic models can provide statistical amplification, few-shot generalization, and mechanistic insight into shared dynamical structure, individual variation, and the control objectives that govern behavior. This agenda offers a model-centric path from fragmented data to a mechanistic science of how brains produce behavior.
| Comments: | Perspective |
| Subjects: | Neurons and Cognition (q-bio.NC); Machine Learning (cs.LG) |
| Cite as: | arXiv:2604.23903 [q-bio.NC] |
| (or arXiv:2604.23903v2 [q-bio.NC] for this version) | |
| https://doi.org/10.48550/arXiv.2604.23903 arXiv-issued DOI via DataCite |
Submission history
From: Il Memming Park [view email]
[v1]
Sun, 26 Apr 2026 22:26:28 UTC (2,059 KB)
[v2]
Sun, 18 Oct 2026 07:53:56 UTC (2,376 KB)
来源：arXiv cs.LG + cs.RO + cs.HC · arxiv.org